After a quarter of a century, Oprah Winfrey will be leaving you stay-at-home moms to your own devices as she is ending her daytime reign in September of 2011.

Many of her close friends and colleagues took a moment to respond to the news and, as you would imagine, they all have nothing but the best to say.

Her life partner in crime, Gayle King, assured the press that the decision to leave her daytime days behind was hers and hers alone. Furthermore, she has no doubt that Oprah will find a way to fill the void left behind:

" I think that Oprah always makes the best decision for herself. I really do. And I have a feeling she will come up with some things to do. She has a very full life … We don't need to worry about her filling her time, I promise you that! Life is good for her."

New bestie Ellen DeGeneres made similar comments when addressing her in-studio audience last night, saying:

"Hey listen, I'm going to tell you some news you're going to hear as soon as you go out into the world, when you leave here. Right before I came out here, I got a call from Oprah and she told me that she is announcing that next year will be her last year. It will be her 25th year, and she feels like it's time for her to stop…I don't think I could be here without her. I think she has blazed a trail … She is an amazing woman…She will always be the Queen of Daytime Television."

Ah, but there is another Queen of Daytime who's doesn't think we have seen the last of O. Martha Stewart told reporters that she believes Oprah will be back, once she has had some time off:

"She'll do another show. She's evolving. She's fabulous."

We're sure she will do another show as well. Question is, will she have it air on network TV or her new cable network, OWN?

We'll have to wait and see.

What do U think of O's big move?

[Image via AP Images.]