We really hope this isn't true, but they've been standing by this story for awhile!
The Enquirer is reporting that Penny Marshall is "heartbroken" after both radiation and chemotherapy treatments have not been going well.
Penny's rep continues to deny that she is sick, but apparently a close family friend has said the director is afraid she's losing the cancer battle as the tumor in her liver has spread to other parts of her body.
So very sad — keep fighting, Penny!
[Image via WENN.]