At one point Matt asked about the Anger Management star's biggest regrets, to which Charlie responded:
"I regret not using a condom one or two times when this whole thing happened. I regret ruining Two and a Half Men. I regret not being more involved in my children's lives growing up… But, we can only move forward from today, and they wouldn't call it the past if it wasn't."
The others are more obvious and personal — but does anyone else see him saying his sitcom was "ruined" is yet another dig at replacement Ashton Kutcher?