Could it be true?

She may have a 22 year old boyfriend, but Madonna has already had to deal with menopause?

According to comedienne Rosie O'Donnell, she turned to Madge when her 'hormone things' started kicking in.

Rosie was a guest on the Tyra Banks show when she made the menopause revelation.

"She's [Madonna] great, she's a lot like a big sister. When I started having my hormone things, I'm like, 'What the hell is going on?' she's like, 'Get the cream,'" said RoRo to TyTy.

We're sure that Madge is not happy that she was tied to this old lady stuff on national TV.

And, what cream is it that Ro and Madge use to get through menopause?

We didn't know they made a menopause cream!

Tyra's sit-down with Rosie will air this coming Thursday and Friday.

Wonder if her Madgesty will be watching?!

[Images via WENN.]