David Letterman's 16 Greatest Late Show Moments!
Mourn The Loss Of Derek Shepherd AKA Dr. McDreamy With His Cutest Moments From Greys Anatomy In GIFs!
Any time Madonna was on the air meant that David Letterman was going to be at his best, grill-iest behavior. We wonder if he kept her panties that she gave as a gift? Her F-bomb laden 1994 appearance was a must-see.