They're the two best friends that anyone could have!
The stars, who have worked together in films like The Wedding Singer and 50 First Dates, first came together after Barrymore requested to meet with the 49-year-old funny man during an admittedly low point in her career.
"[I thought] I want to be a modern weird Hepburn, Tracey old Hollywood couple … We looked like the worst blind date you've ever seen. I showed up with purple hair and a leopard coat and he was in his classic cargo pants. As soon as I saw him I was like 'Yeah you're going to have to see past all this.'"
LOLz! We guess opposites attract!
So how'd she convince him? The E.T. star said: